MORPHOLOGICAL TRANSFORMATION OF THE INTESTINAL WALL IN NEWBORNS WITH NECROTISING ENTEROCOLITIS

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Abstract


The purpose is to present morphological and morphometric changes in the histoarchitecture of the intestinal wall in newborns with necrotizing enterocolitis considering the outcomes of the disease. Materials and methods. The PRMU clinics carried out a morphological study of histological intestinal sections of 99 operated patients with NEC from 2003 to 2017. The patients were divided into the following groups: 72 survived newborns from group I (favourable outcome) and 27 dead newborns from group II (unfavourable outcome). The object under study was surgical specimen of the ileum and large intestine. Result. The disease outcome can be predicted using morphological changes in the intestinal wall in NEC. The leading role of the drainage function of the lymphatic apparatus is established in the article. It is completely restructured in the operational specimen of patients with the unfavourable course. Changes in the cellular composition in the form of insufficient number of fibroblast cells and isolated epithelial and stromal cells enabled subsequent destruction of the bowel wall with progression of the exudative processes.

About the authors

I. Yu. Karpova

Privolzhsky Research Medical University

Author for correspondence.
Email: ikarpova73@mail.ru

Russian Federation

Irina Yu. KARPOVA - Dr. Sci. (Med.), associate professor, professor of the Department of Pediatric Surgery

10/1, pl. Minin and Pozharsky, Nizhny Novgorod, 603005

V. V. Parshikov

Privolzhsky Research Medical University

Email: fake@neicon.ru

Russian Federation

Vyacheslav V. PARSHIKOV - Dr. Sci. (Med.), professor, head of the Department of Pediatric Surgery

10/1, pl. Minin and Pozharsky, Nizhny Novgorod, 603005

N. Yu. Shirokova

Privolzhsky Research Medical University

Email: fake@neicon.ru

Russian Federation

Natalia Yu. SHIROKOVA - Cand. sci. (Biol.), senior researcher, pathological anatomy group

10/1, pl. Minin and Pozharsky, Nizhny Novgorod, 603005

Е. D. Pyatova

Privolzhsky Research Medical University

Email: fake@neicon.ru

Russian Federation

Evgenia D. PYATOVA - Senior lecturer of the Department of Medical Physics and Informatics

10/1, pl. Minin and Pozharsky, Nizhny Novgorod, 603005

D. V. Molchanova

Children’s City Clinical Hospital № 27

Email: fake@neicon.ru

Russian Federation

Daria V. MOLCHANOVA - Doctor – pediatric surgeon

7A, Yaroshenko st., Nizhny Novgorod, 603035

A. A. Bebenina

Privolzhsky Research Medical University

Email: fake@neicon.ru

Russian Federation

Anastasia A. Bebenina  - 6th year student of the Pediatric Faculty

10/1, pl. Minin and Pozharsky, Nizhny Novgorod, 603005

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