RISK FACTORS OF CHRONIC RENAL DISEASE PROGRESSION IN CHILDREN WITH CONGENITAL DEFECTS OF THE URINARY TRACT IN THE POSTOPERATIVE PERIOD

Cover Page

Abstract


The purpose of the study was to find independent and attributive predictors of progression of chronic renal disease (CRD) in children who underwent a surgery for congenital defects of the urinary tracts.

Methods. It was a retrospective, observational and cohort study. The inclusion criteria were congenital abnormality of the kidneys and urinary tracts, glomerular filtration rate (GFR) <90 ml/min/1.73 m2, patients less than 18 years old. 297 patients were included in the study. The data were statistically processed using «Statistica 6.0» and MedCalc (MedCalcSoftware, Belgium).

Results. We found out that the glomerular filtration rate at the stage of primary hospitalization (RR = 9.40) and arterial hypertension (OR = 4.40) were the only independent predictors of the CRD progression. The combination of the two types were shown using the area under ROC-curve (0.756) which was significantly (р<0.005) higher than the isolated value of the symptoms.

Conclusions. The attributive risk factor of CRD progression in children who had a surgery for congenital defects of the urinary tracts is arterial hypertension (AH). The independent risk factor are GFR and AH. Their combination significantly increases the risk (р<0.005) of chronic renal disease progression.


About the authors

R. Z. Akhmetshin

Bashkortostan State Medical University, Ufa

Email: fake@neicon.ru

Russian Federation Кандидат медицинских наук, зав. кафедрой педиатрии ИДПО

P. I. Mironov

Bashkortostan State Medical University, Ufa

Author for correspondence.
Email: mironovpi@mail.ru

Russian Federation Доктор медицинских наук, профессор кафедры детской хирургии с курсом ИДПО

References

  1. Urology. The national guidance / ed. Lopatkina. M.: GEOTAR-Media, 2009 (in Russian) Урология. Национальное руководство / под ред. Н. А. Лопаткина. M.: ГЕОТАР-Медиа, 2009.
  2. Nephrology children’s age / Under the editorship of V. A. Tabolina, S. V. Belmer, I. M. Osmanov. M.: Medpraktika, 2005 (in Russian) Нефрология детского возраста / под ред. В. А. Таболина, С. В. Бельмера, И. М. Османова. М.: Медпрактика, 2005.
  3. Chiu H. L., Tangri N., Djurdiev О., et al. Perceptions of prognostic risks in chronic kidney disease: a national survey // Canadian J of Kidney health and disease 2015 2: 53.
  4. Heinlen J. E., Manatt C. S., Bright B. C., et al. Operative versus nonoperative management of ureteropelvic junction obstruction in children // Urology 2009 Mar;73 (3):521e5. discussion 525. [Epub 2008 Dec 18].
  5. Shahinian V. B., Hedgeman E., Gillespie B. W., et al. Estimating prevalence of CKD stages 3–5 using health system data // Am J Kidney Dis. 2013;61 (6):930–8.
  6. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidnei International supll. 2013; 1: 163p.
  7. Ross S. S., Kordos S., Krill A., et al. Observation of infant with SFU Grades 3–4 hydronephrosis: Worsening drainage with serial diuresis renography indicates surgical intervention and help prevent loss renal function // J Pediatric Urology 2011, 7. 266–271.
  8. Dupius D., Ducllet G., RoyL. Retrospective analysis of the predictive factors of renal functions loss after uninephroectomy in patients with chronic kidney disease G3 to G5 // Canadian J of Kidney health and disease 2015, 2: 52.

Statistics

Views

Abstract - 86

PDF (Russian) - 0

Refbacks

  • There are currently no refbacks.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies